The MIIS Eprints Archive

Discovery and Assessment of New Target Sites for Anti-HIV Therapies

Breward, C. and Heffernan, J. and Madras, N. and Miura, R. and Sorensen, M. (2008) Discovery and Assessment of New Target Sites for Anti-HIV Therapies. [Study Group Report]



Human immunodeficiency virus (HIV) infects cells by endocytosis and takes over parts of the cell’s reaction pathways in order to reproduce itself and spread the infection. One such pathway taken over by HIV becomes the inflammatory pathway which uses Nuclear Factor κB (NF-κB) as the principal transcription factor. Therefore, knocking out the NF-κB pathway would prevent HIV from reproducing itself. In this report, our goal is to produce a simple model for this pathway with which we can identify potential targets for anti-HIV therapies and test out various hypotheses. We present a very simple model with four coupled first-order ODEs and see what happens if we treat IκK concentration as a parameter that can be controlled (by some unspecified means). In Section 3, we augment this model to account for activation and deactivation of IκK, which is controlled (again, by some unspecified means) by TNF.

Item Type:Study Group Report
Problem Sectors:Medical and pharmaceutical
Study Groups:Canadian Industrial Problem Solving Workshops > FM-IPSW 2008 (Toronto, Canada, Aug 11-15, 2008)
Company Name:Gustavus Adolphus College, USA
ID Code:570
Deposited By: Mark Curtis
Deposited On:29 Feb 2012 18:27
Last Modified:29 May 2015 20:11

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