eprintid: 136
rev_number: 4
eprint_status: archive
userid: 5
dir: disk0/00/00/01/36
datestamp: 2008-05-20
lastmod: 2015-05-29 19:48:02
status_changed: 2009-04-08 16:54:42
type: report
metadata_visibility: show
item_issues_count: 0
creators_name: Wattis, Jonathan
contributors_name: Pickersgill, Laura
contributors_name: MacDonald, Ian
contributors_name: Byrne, Helen
contributors_name: Hjorth, Poul
contributors_name: King, John
contributors_name: Lock, Anthony
contributors_name: Locsei, Tobias
contributors_name: McCullen, Nick
contributors_name: Miller, Joanne
contributors_name: Pitcher, Ashley
contributors_name: Ward, John
title: Skeletal muscle fuel utilisation in healthy and disregulated states
ispublished: pub
subjects: food
subjects: medicine
studygroups: esgi59
companyname: Unilever
full_text_status: public
problem_statement: In healthy lean subjects, skeletal muscle displays metabolic flexibility, that
is, it is capable of switching between predominantly lipid oxidation with high
rates of fatty acid uptake during fasting conditions, and the suppression of
lipid oxidation in favour of increased glucose uptake, oxidation and storage
in response to insulin during the fed state. Insulin resistant states such as
obesity and Type 2 diabetes are characterised by this loss of, or reduction in,
fuel-switching ability. The aim is to develop a mathematical model of skeletal
muscle fuel utilisation, that will enable an investigation of the dynamics of
skeletal muscle glucose and lipid handling in response to a meal, as well as
the effects of insulin on these dynamics.
date: 2007-08-31
date_type: published
pages: 18
citation:   Wattis, Jonathan  (2007) Skeletal muscle fuel utilisation in healthy and disregulated states.  [Study Group Report]     
document_url: http://miis.maths.ox.ac.uk/miis/136/1/skeletal.pdf