?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F340%2F&rft.title=Mediators+of+mechanotransduction+between+bone+cells&rft.creator=Komarova%2C+S.+V.&rft.creator=Lopez%2C+M.&rft.creator=Miura%2C+R.+M.&rft.creator=Qazi%2C+S.&rft.creator=Wall%2C+D.+J.+N.&rft.subject=Medical+and+pharmaceutical&rft.description=Mechanical+forces+are+known+to+regulate+the+function+of+tissues+in+the+body%2C+including+bone.+Bone+adapts+to+its+mechanical+environment+by+altering+its+shape+and+increasing+its+size+in+response+to+increases+in+mechanical+load+associated+with+exercise%2C+and+by+decreasing+its+size+in+response+to+decreases+in+mechanical+load+associated+with+microgravity+or+prolonged+bed+rest.+Changes+in+bone+size+and+shape+are+produced+by+a+cooperative+action+of+two+main+types+of+the+bone+cells+-+osteoclasts+that+destroy+bone+and+osteoblasts+that+build+bone.+These+cell+types+come+from+different+developmental+origins%2C+and+vary+greatly+in+their+characteristics%2C+such+as+size%2C+shape%2C+and+expression+of+receptor+subtypes%2C+which+potentially+may+affect+their+responses+to+mechanical+stimuli.+The+objective+of+this+study+is+to+compare+the+responses+of+osteoclasts+and+osteoblasts+to+mechanical+stimulation.%0D%0A%0D%0AThis+study+has+allowed+us+to+conclude+the+following%3A%0D%0A1.+A+mediator+is+released+from+a+single+source+cell.%0D%0A2.+The+response+to+the+mediator+changes+with+distance.%0D%0A3.+The+value+of+the+apparent+diffusion+coeficient+increases+with+distance.%0D%0A4.+A+plausible+proposed+mechanism+is+that+ATP+is+released+and+degrades+to+ADP.%0D%0A5.+Future+experiments+are+required+to+confim+that+ATP+is+the+mediator+as+suggested.&rft.date=2009&rft.type=Study+Group+Report&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F340%2F1%2FMechanotransduction.pdf&rft.identifier=++Komarova%2C+S.+V.+and+Lopez%2C+M.+and+Miura%2C+R.+M.+and+Qazi%2C+S.+and+Wall%2C+D.+J.+N.++(2009)+Mediators+of+mechanotransduction+between+bone+cells.++%5BStudy+Group+Report%5D+++++