eprintid: 342
rev_number: 13
eprint_status: archive
userid: 7
dir: disk0/00/00/03/42
datestamp: 2011-07-27 17:56:54
lastmod: 2015-05-29 19:57:58
status_changed: 2011-07-27 17:56:54
type: report
metadata_visibility: show
item_issues_count: 0
creators_name: Anvari, V.
creators_name: Atapour, M.
creators_name: Bourouiba, L.
creators_name: Caudillo Mata, L. A.
creators_name: Collinson, S.
creators_name: Johnson, A.
creators_name: Madras, N.
creators_name: Miasnikof, P.
creators_name: Ramirez Ramirez, L. L.
creators_name: Sanchez-Bravo, I.
corp_creators: Susie El Saadany
corp_creators: Mustafa Al-Zoughool (University of Ottawa)
title: Mathematical Models for Estimating the Risk of vCJD Transmission
ispublished: pub
subjects: medicine
studygroups: cbmpsw1
companyname: Public Health Agency of Canada
full_text_status: public
abstract: We present two different simple models for vCJD transmission by blood transfusion. Both models indicate that transfusions alone are unlikely to cause more than a few infections, unless the number of primary cases increases.

To improve our models, future work should pursue data collection, empirical estimation of the model parameters, and examination of the underlying assumptions of our frameworks.

Further improvements could also include examining susceptibility to vCJD infection by age group and iatrogenic infections introduced through surgical instruments. Regarding the latter, it may be worthwhile to conduct experiments to quantify the transmission of prions from an infected surgical instrument after repeated sterilization procedures.
date: 2009
citation:   Anvari, V. and Atapour, M. and Bourouiba, L. and Caudillo Mata, L. A. and Collinson, S. and Johnson, A. and Madras, N. and Miasnikof, P. and Ramirez Ramirez, L. L. and Sanchez-Bravo, I.  (2009) Mathematical Models for Estimating the Risk of vCJD Transmission.  [Study Group Report]     
document_url: http://miis.maths.ox.ac.uk/miis/342/1/vCJD.pdf