?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F5%2F&rft.title=Protein+evolution&rft.creator=Hjorth%2C+P&rft.subject=Medical+and+pharmaceutical&rft.description=Among+the+proteins+that+have+evolved+over+hundreds+of+millions+of+years%2C+with+important+roles+in+defence+against+invading+micro-organisms%2C+are+the+pentraxins.+The+two+major+members+of+the+family+are+known+as+CRP+and+SAP%2C+and+they+evolve+due+to+mutations+in+the+underlying+DNA.+The+Study+Group+was+asked+to+construct+a+model+of+this+evolution+in+order+to+answer+specific+questions+about+the+occurrences+of+these+proteins+in+man+and+in+the+horseshoe+crab.&rft.date=2001-04&rft.type=Study+Group+Report&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F5%2F1%2FProtein.pdf&rft.identifier=++Hjorth%2C+P++(2001)+Protein+evolution.++%5BStudy+Group+Report%5D+++++