?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F568%2F&rft.title=Optimal+Treatment+Rate+During+an+Influenza+Pandemic+in+the+Presence+of+Drug-Resistance+Emergence&rft.creator=Arino%2C+J.&rft.subject=Medical+and+pharmaceutical&rft.description=The+problem+was+posed+by+Seyed+Moghadas%2C+from+the+National+Research+Council+Institute+for+Biodiagnostics+in+Winnipeg%2C+Manitoba.+It+concerns+the+optimization+of+the+rate+of+treatment+with+antivirals+during+a+pandemic+of+influenza%2C+to+achieve+the+following+objectives%3A%0D%0A1.+Minimize+the+total+number+of+deaths+due+to+influenza.%0D%0A2.+Minimize+the+total+number+of+infections+with+influenza.%0D%0A3.+Reduce+the+spread+of+resistance+to+antivirals.%0D%0AIt+is+understood+that+not+all+the+objectives+above+might+be+satisfied+at+the+same+time%2C+and+the+purpose+of+the+work+is+to+consider+the+outcome+in+the+different+scenarios.+The+aim+of+the+present+project+is+to+see+if+optimal+control+theory+can+contribute+to+a+better+formulation+of+the+treatment+intensity%2C+in+order+to+bring+the+epidemic+under+control+while+avoiding+wide-spread+resistance+in+the+population.&rft.date=2008&rft.type=Study+Group+Report&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F568%2F1%2F1.pdf&rft.identifier=++Arino%2C+J.++(2008)+Optimal+Treatment+Rate+During+an+Influenza+Pandemic+in+the+Presence+of+Drug-Resistance+Emergence.++%5BStudy+Group+Report%5D+++++