?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F570%2F&rft.title=Discovery+and+Assessment+of+New+Target+Sites+for+Anti-HIV+Therapies&rft.creator=Breward%2C+C.&rft.creator=Heffernan%2C+J.&rft.creator=Madras%2C+N.&rft.creator=Miura%2C+R.&rft.creator=Sorensen%2C+M.&rft.subject=Medical+and+pharmaceutical&rft.description=Human+immunodeficiency+virus+(HIV)+infects+cells+by+endocytosis+and+takes+over+parts+of+the+cell%E2%80%99s+reaction+pathways+in+order+to+reproduce+itself+and+spread+the+infection.+One+such+pathway+taken+over+by+HIV+becomes+the+inflammatory+pathway+which+uses+Nuclear+Factor+%CE%BAB+(NF-%CE%BAB)+as+the+principal+transcription+factor.+Therefore%2C+knocking+out+the+NF-%CE%BAB+pathway+would+prevent+HIV+from+reproducing+itself.+In+this+report%2C+our+goal+is+to+produce+a+simple+model+for+this+pathway+with+which+we+can+identify+potential+targets+for+anti-HIV+therapies+and+test+out+various+hypotheses.+We+present+a+very+simple+model+with+four+coupled+first-order+ODEs+and+see+what+happens+if+we+treat+I%CE%BAK+concentration+as+a+parameter+that+can+be+controlled+(by+some+unspecified+means).+In+Section+3%2C+we+augment+this+model+to+account+for+activation+and+deactivation+of+I%CE%BAK%2C+which+is+controlled+(again%2C+by+some+unspecified+means)+by+TNF.&rft.date=2008&rft.type=Study+Group+Report&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F570%2F1%2F3.pdf&rft.identifier=++Breward%2C+C.+and+Heffernan%2C+J.+and+Madras%2C+N.+and+Miura%2C+R.+and+Sorensen%2C+M.++(2008)+Discovery+and+Assessment+of+New+Target+Sites+for+Anti-HIV+Therapies.++%5BStudy+Group+Report%5D+++++