?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F68%2F&rft.title=Lipid+Metabolism+and+Comparative+Genomics&rft.creator=Tindall%2C+Marcus&rft.creator=Rougier%2C+Jonathan&rft.creator=Pickersgill%2C+Laura&rft.creator=Melrose%2C+John&rft.creator=O%E2%80%99Malley%2C+Brendan&rft.creator=Jones%2C+Janette&rft.subject=Food+and+Drink&rft.subject=Medical+and+pharmaceutical&rft.description=Unilever+asked+the+Study+Group+to+focus+on+two+problems.+The+first+concerned+dysregulated+lipid+metabolism+which+is+a+feature+of+many+diseases+including+metabolic+syndrome%2C+obesity+and+coronary+heart+disease.+The+Study+Group+was+asked+to+develop+a+model+of+the+kinetics+of+lipoprotein+metabolism+between+healthy+and+obese+states+incorporating+the+activities+of+key+enzymes.%0A%0AThe+second+concerned+the+use+of+comparative+genomics+in+understanding+and+comparing+metabolic+networks+in+bacterium.+Comparative+genomics+is+a+method+to+make+inferences+on+the+genome+of+a+new+organism+using+information+of+a+previously+charaterised+organism.+The+first+mathematical+question+is+how+one+would+quantify+such+a+metabolic+map+in+a+statistical+sense%2C+in+particular%2C+where+there+are+different+levels+of+confidence+for+presense+of+different+parts+of+the+map.+The+next+and+most+important+question+is+how+one+can+design+a+measurement+strategy+to+maximise+the+confidence+in+the+accuracy+of+the+metabolic+map.&rft.date=2006&rft.type=Study+Group+Report&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F68%2F1%2FUnilever-report.pdf&rft.identifier=++Tindall%2C+Marcus+and+Rougier%2C+Jonathan+and+Pickersgill%2C+Laura+and+Melrose%2C+John+and+O%E2%80%99Malley%2C+Brendan+and+Jones%2C+Janette++(2006)+Lipid+Metabolism+and+Comparative+Genomics.++%5BStudy+Group+Report%5D+++++