?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F70%2F&rft.title=Capillary+Agglutination+Technology&rft.creator=Breward%2C+Chris&rft.creator=Richardson%2C+Giles&rft.subject=Medical+and+pharmaceutical&rft.description=In+medical+diagnostic+tests%2C+including+pregnancy+testing+and+tests+for+typed+red+blood+cells%2C+a+small+fluid+sample+is+placed+at+one+end+of+a+capillary+channel%2C+which+has+been+lined+with+a+dried+reagent.+If+the+sample+contains+the+analyte+(the+substance+being+tested+for)+then+an+agglutination+reaction+occurs+between+it+and+the+reagent+in+the+channel%2C+and+the+agglutinated+complexes+progressively+slow+the+flow+and+may+even+block+the+channel%2C+partially+or+completely%2C+so+that+the+flow+only+reaches+the+far+end+very+slowly%2C+or+not+at+all.+The+aim+is+that+this+should+give+a+reliable+detection+of+quite+low+concentrations+of+analyte+in+the+sample.+Platform+Diagnostics+asked+the+Study+Group+to+construct+a+mathematical+model+of+the+process%2C+so+that%2C+for+known+binding+forces+in+the+agglutination+complexes%2C+we+can+design+the+channel+size+and+shape%2C+and+the+fluid+viscosity%2C+to+maximize+the+reliable+detection+of+low+concentrations.+A+key+question+is+how+the+flow+time+depends+on+channel+size%2C+fluid+surface+tension+and+viscosity%2C+(a)+in+the+absence+of+agglutination%2C+and+(b)+in+the+presence+of+agglutination.&rft.date=2006&rft.type=Study+Group+Report&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F70%2F1%2FPlatformDiagnostics-report.pdf&rft.identifier=++Breward%2C+Chris+and+Richardson%2C+Giles++(2006)+Capillary+Agglutination+Technology.++%5BStudy+Group+Report%5D+++++