Optical Measurement of Glucose Content of the Aqueous Humor
Dan Daly and Graeme Clark, Lein Applied Diagnostics
Many diabetics must measure their blood glucose levels regularly to maintain good health (Appendix 1). In principle, one way of measuring the glucose concentration in the human body would be by measuring optically the glucose content of the aqueous humor in the eye.
Lein Applied Diagnostics wish to assess how feasible this is,
The sensitivity of the refractive index of the aqueous humor to the glucose concentration is of the order of one part in 105 for a change in glucose concentration of 5mg/dl, and concentrations of between 50mg/dl and 400mg/dl need to be detected reliably.
The use of a confocal scanning technique enables one to measure the optical depth of the aqueous humor to this required accuracy. The optical depth, D, is given by L/n where L is the physical depth of the anterior chamber and n is the refractive index of the aqueous humor. This direct measurement cannot be made in practice as the real depth of the anterior chamber changes due to corneal swelling and accommodation of the ocular lens.
The appendices are contained in the pdf problem description.
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by C. Breward