?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F200%2F&rft.title=A+mathematical+model+of+the+tetrapyrrole+biosynthesis+pathway&rft.creator=Ward%2C+John&rft.creator=Moulin%2C+Michael&rft.creator=Feugier%2C+Francois&rft.creator=Hazledine%2C+Saul&rft.subject=None%2FOther&rft.description=The+tetrapyrrole+biosynthesis+pathway+is+a+key+part+in+chlorophyll+production+and+is+essential+for+plant+survival.+It+involves+numerous+interacting+compounds+and%2C+crucially%2C+light.+The+understanding+of+the+complex+regulation+processes+involved+has+been+the+focus+of+extensive+experimental+research+providing+a+large+source+of+data.+A+particular+set+of+data%2C+concerned+with+the+modelling+described+in+this+report%2C+involves+24+hour+timecourse+data+from+seedlings+exposed+to+constant+light%2C+following+a+three+day+period+of+growth+from+seed+in+darkness.+This+data+includes+the+levels+of+key+components+such+as+chlorophyll%2C+ATP%2C+chlorophyllide+and+proto-chlorophyllide.+Amongst+the+questions+posed+in+the+study-group+were%3A+i)+Can+the+timecourse+data+be+predicted+by+a+model%3F+ii)+Can+it+predict+the+dierences+in+levels+of+various+components+in+found+mutant+strains.%0A%0ATo+address+these+questions%2C+we+present+in+this+report+a+model+consisting+of+a+coupled+system+of+nonlinear+ODEs+that+describes+a+simplied+version+of+the+tetrapyrrole+pathway+based+on+mass+action+laws.+Model+simulations+produced+results+that+agree+qualitatively+well+with+most%2C+but+not+all%2C+of+the+available+timecourse+data+obtained+from+wild-type+and+mutant+strains.+Nearly+all+of+the+model's+parameters+are+not+known%2C+so+the+values+used+in+these+simulations+are+based+on+estimates+of+the+relative+timescales+of+the+reactions.+An+attempt+at+improving+these+estimates+using+data+tting+techniques+is+also+discussed.&rft.date=2007-12&rft.type=Study+Group+Report&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F200%2F1%2Freport4.pdf&rft.identifier=++Ward%2C+John+and+Moulin%2C+Michael+and+Feugier%2C+Francois+and+Hazledine%2C+Saul++(2007)+A+mathematical+model+of+the+tetrapyrrole+biosynthesis+pathway.++%5BStudy+Group+Report%5D+++++