?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F339%2F&rft.title=A+Mechanism+for+Ventricular+Expansion+in+Communicating+Hydrocephalus&rft.creator=Begg%2C+R.&rft.creator=Wilkie%2C+K.&rft.subject=Medical+and+pharmaceutical&rft.description=This+report+investigates+a+new+possible+molecular+mechanism+for+the+pathogenesis+of+hydrocephalus.+New+research+by+Dr.+Miles+Johnston+has+found+that+the+injection+of+anti+beta_1+integrin+antibodies+into+the+ventricle+of+rats+causes+a+drop+in+parenchymal+pressure+and+causes+the+cerebral+ventricles+to+enlarge+which+is+characteristic+of+hydrocephalus.+We+investigate+intramantle+pressure+gradients+as+a+possible+force+to+enlarge+the+ventricles+and+we+propose+a+new+poroelastic+model+incorporating+the+effect+of+the+antibodies+to+determine+if+they+are+a+possible+mechanism+for+hydrocephalus.&rft.date=2009&rft.type=Study+Group+Report&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F339%2F1%2FHydrocephalus.pdf&rft.identifier=++Begg%2C+R.+and+Wilkie%2C+K.++(2009)+A+Mechanism+for+Ventricular+Expansion+in+Communicating+Hydrocephalus.++%5BStudy+Group+Report%5D+++++