eprintid: 339
rev_number: 9
eprint_status: archive
userid: 7
dir: disk0/00/00/03/39
datestamp: 2011-07-27 17:37:48
lastmod: 2015-05-29 19:57:47
status_changed: 2011-07-27 17:37:48
type: report
metadata_visibility: show
item_issues_count: 0
creators_name: Begg, R.
creators_name: Wilkie, K.
corp_creators: Miles Johnston
title: A Mechanism for Ventricular Expansion in Communicating Hydrocephalus
ispublished: pub
subjects: medicine
studygroups: cbmpsw1
companyname: Sunnybrook Health Sciences Centre
full_text_status: public
abstract: This report investigates a new possible molecular mechanism for the pathogenesis of hydrocephalus. New research by Dr. Miles Johnston has found that the injection of anti beta_1 integrin antibodies into the ventricle of rats causes a drop in parenchymal pressure and causes the cerebral ventricles to enlarge which is characteristic of hydrocephalus. We investigate intramantle pressure gradients as a possible force to enlarge the ventricles and we propose a new poroelastic model incorporating the effect of the antibodies to determine if they are a possible mechanism for hydrocephalus.
date: 2009
citation:   Begg, R. and Wilkie, K.  (2009) A Mechanism for Ventricular Expansion in Communicating Hydrocephalus.  [Study Group Report]     
document_url: http://miis.maths.ox.ac.uk/miis/339/1/Hydrocephalus.pdf