eprintid: 70
rev_number: 4
eprint_status: archive
userid: 4
dir: disk0/00/00/00/70
datestamp: 2006-06-19
lastmod: 2015-05-29 19:46:42
status_changed: 2009-04-08 16:53:31
type: report
metadata_visibility: show
item_issues_count: 0
creators_name: Breward, Chris
creators_name: Richardson, Giles
creators_id: breward@maths.ox.ac.uk
creators_id: 
contributors_name: Bond, Philip
contributors_name: Booth, Richard
contributors_name: Clarke, Richard
contributors_name: Cummings, Linda
contributors_name: Dellar, Paul
contributors_name: Duchemin, Laurent
contributors_name: Dyson, Rosemary
contributors_name: Evatt, Geoff
contributors_name: Gelder, David
contributors_name: Griffiths, Ian
contributors_name: Heil, Matthias
contributors_name: Juel, Anne
contributors_name: King, John
contributors_name: Lacey, Andrew
contributors_name: Naire, Shailesh
contributors_name: Nakane, Kazuaki
contributors_name: Ockendon, John
contributors_name: Please, Colin
contributors_name: White, Gordon
contributors_name: Zammett, Rachel
contributors_id: 
contributors_id: boothr@maths.ox.ac.uk
contributors_id: 
contributors_id: 
contributors_id: 
contributors_id: 
contributors_id: dysonr@maths.ox.ac.uk
contributors_id: evatt@maths.ox.ac.uk
contributors_id: 
contributors_id: griffit4@maths.ox.ac.uk
contributors_id: 
contributors_id: 
contributors_id: 
contributors_id: 
contributors_id: 
contributors_id: 
contributors_id: 
contributors_id: 
contributors_id: whitegs@maths.ox.ac.uk
contributors_id: zammettr@maths.ox.ac.uk
title: Capillary Agglutination Technology
ispublished: pub
subjects: medicine
studygroups: esgi53
companyname: Platform Diagnostics Limited
full_text_status: public
abstract: In medical diagnostic tests, including pregnancy testing and tests for typed red blood cells, a small fluid sample is placed at one end of a capillary channel, which has been lined with a dried reagent. If the sample contains the analyte (the substance being tested for) then an agglutination reaction occurs between it and the reagent in the channel, and the agglutinated complexes progressively slow the flow and may even block the channel, partially or completely, so that the flow only reaches the far end very slowly, or not at all. The aim is that this should give a reliable detection of quite low concentrations of analyte in the sample. Platform Diagnostics asked the Study Group to construct a mathematical model of the process, so that, for known binding forces in the agglutination complexes, we can design the channel size and shape, and the fluid viscosity, to maximize the reliable detection of low concentrations. A key question is how the flow time depends on channel size, fluid surface tension and viscosity, (a) in the absence of agglutination, and (b) in the presence of agglutination.
problem_statement: In medical diagnostic tests, including pregnancy testing and tests for typed red blood cells, a small fluid sample is placed at one end of a capillary channel, which has been lined with a dried reagent. If the sample contains the analyte (the substance being tested for) then an agglutination reaction occurs between it and the reagent in the channel, and the agglutinated complexes progressively slow the flow and may even block the channel, partially or completely, so that the flow only reaches the far end very slowly, or not at all. The aim is that this should give a reliable detection of quite low concentrations of analyte in the sample. Platform Diagnostics would like a mathematical model of the process, so that, for known binding forces in the agglutination complexes, the channel size and shape, and the fluid viscosity, can be designed to maximize the reliable detection of low concentrations. A key question is how the flow time depends on channel size, fluid surface tension and viscosity, (a) in the absence of agglutination, and (b) in the presence of agglutination.
date: 2006
date_type: published
pages: 18
citation:   Breward, Chris and Richardson, Giles  (2006) Capillary Agglutination Technology.  [Study Group Report]     
document_url: http://miis.maths.ox.ac.uk/miis/70/1/PlatformDiagnostics-report.pdf