?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F83%2F&rft.title=The+mathematical+modelling+of+cooling+and+rewarming+patients+during+cardiac+surgery&rft.creator=Tindall%2C+Marcus&rft.creator=Peletier%2C+Mark&rft.creator=Aitchison%2C+Joyce&rft.creator=van+Mourik%2C+Simon&rft.creator=Severens%2C+Natascha&rft.subject=Medical+and+pharmaceutical&rft.description=The+process+of+cooling+bodies%2C+by+the+use+of+a+heart+lung+machine+(HLM)%2C+is+utilised+in+a+number+of+surgical+procedures+primarily+to+reduce+the+metabolic+rate+of+the+organs+and+hence+their+consumption+of+oxygen.+On+completion+of+surgery+the+blood+is+rewarmed+by+the+HLM.+A+major+consequence+at+the+end+of+this+process+is+afterdrop%3A+a+rapid+decrease+in+the+core+organ+temperature+as+a+result+of+spatial+temperature+differences+between+the+core+organs+and+remainder+of+the+body%2C+which+can+lead+to+post-operative+complications.+This+report+details+two+mathematical+models+developed+to+understand+heat+transfer+processes+between+the+core+organs%2C+rectal+region+and+peripheral+body+parts+(primarily+skin%2C+muscle+and+fat).+A+one+compartment+spatially+independent+model%2C+describing+the+temperature+distribution+of+a+single+tissue+type+through+which+blood+perfuses%2C+shows+that+temperature+dependent+perfusion+reproduces+the+observed+differences+in+blood+and+tissue+temperatures%2C+whilst+temperature+independent+perfusion+does+not.+The+model+is+extended+to+account+for+heat+transfer+between+the+blood+pool+(core)%2C+rectal+regions+and+periphery.+This+three+compartmental+model+is+able+to+qualitatively+reproduce+the+observed+temperature+differences+in+the+three+regions.+Analysis+of+the+model+shows+that+a+period+of+constant+warming+at+the+end+of+the+rewarming+period+has+a+positive+effect+in+reducing+afterdrop.&rft.date=2005-02-04&rft.type=Study+Group+Report&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fmiis.maths.ox.ac.uk%2Fmiis%2F83%2F1%2Fwarmup.pdf&rft.identifier=++Tindall%2C+Marcus+and+Peletier%2C+Mark+and+Aitchison%2C+Joyce+and+van+Mourik%2C+Simon+and+Severens%2C+Natascha++(2005)+The+mathematical+modelling+of+cooling+and+rewarming+patients+during+cardiac+surgery.++%5BStudy+Group+Report%5D+++++